Nintedanib
CAS#: 656247-17-5 (or 928326-83-4)
Description: Nintedanib, also known as BIBF 1120, is an orally bioavailable inhibitor of vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR) and platelet derived growth factor receptor (PDGFR). Intedanib selectively binds to and inhibits vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR) and platelet-derived growth factor receptor (PDGFR) tyrosine kinases, which may result in the induction of endothelial cell apoptosis; a reduction in tumor vasculature; and the inhibition of tumor cell proliferation and migration. On 11/15/2014 , FDA approved Nintedanib for the treatment of idiopathic pulmonary fibrosis (IPF).
Synonym: BIBF1120; BIBF 1120; BIBF-1120; Nintedanib. Brand name: Vargatef.
IUPAC/Chemical Name: (Z)-methyl 3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
THEORETICAL ANALYSIS
Name: Nintedanib
CAS#: 656247-17-5 (or 928326-83-4)
Chemical Formula: C31H33N5O4
Exact Mass: 539.25325
Molecular Weight: 539.62
Elemental Analysis: C, 69.00; H, 6.16; N, 12.98; O, 11.86
TECHNICAL DATA
ADDITIONAL INFORMATION
Related: CAS#
656247-18-6 (Nintedanib esylate)
656247-17-5 (Nintedanib free base)
928326-83-4 (previously assigned to Nintedanib free base)
REFERENCES
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