Chidamide
CAS#: 743420-02-2
Description: Chidamide, also known as CS055 and HBI-8000 , is a n orally bioavailable benzamide type inhibitor of histone deacetylase (HDAC) isoenzymes 1, 2, 3 and 10, with potential antineoplastic activity. Chidamide selectively binds to and inhibits HDAC leading to an increase of acetylation levels of histone protein H3. This agent also inhibits the expression of signaling kinases in the PI3K/Akt and MAPK/Ras signaling pathways and may result in cell cycle arrest and the induction of tumor cell apoptosis. This may inhibit tumor cell proliferation in susceptible tumor cells.
Synonym: CS055; CS-055; CS 055; HBI8000; HBI 8000; HBI-8000; Chidamide.
IUPAC/Chemical Name: (E)-N-(2-amino-5-fluorophenyl)-4-((3-(pyridin-3-yl)acrylamido)methyl)benzamide
THEORETICAL ANALYSIS
Name: Chidamide
CAS#: 743420-02-2
Chemical Formula: C22H19FN4O2
Exact Mass: 390.1492
Molecular Weight: 390.41
Elemental Analysis: C, 67.68; H, 4.91; F, 4.87; N, 14.35; O, 8.20
TECHNICAL DATA
REFERENCES
1: Wong JC, Guo L, Peng Z, Zhang W, Zhang N, Lai W, Zhang Z, Zhang C, Zhang X, Song S, Pan D, Xie C, Li J, Ning Z, Lu X, He Y, Chen L. Application of p21 and klf2 reporter gene assays to identify selective histone deacetylase inhibitors for cancer therapy. Bioorg Med Chem Lett. 2011 Jan 1;21(1):110-6. Epub 2010 Nov 19. PubMed PMID: 21145737.
