Lenvatinib mesylate
CAS#: 417716-92-8 (mesylate)
Description: Lenvatinib, also known as E7080, is a synthetic, orally available inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2, also known as KDR/FLK-1) tyrosine kinase with potential antineoplastic activity. E7080 blocks VEGFR2 activation by VEGF, resulting in inhibition of the VEGF receptor signal transduction pathway, decreased vascular endothelial cell migration and proliferation, and vascular endothelial cell apoptosis.
Synonym: E7080; E-7080; E 7080; Lenvatinib; Lenvatinib mesylate; trade name Lenvima.
IUPAC/Chemical Name: 4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-methoxyquinoline-6-carboxamide mesylate
THEORETICAL ANALYSIS
Name: Lenvatinib mesylate
CAS#: 417716-92-8 (mesylate)
Chemical Formula: C22H23ClN4O7S
Exact Mass:
Molecular Weight: 522.96
Elemental Analysis: C, 50.53; H, 4.43; Cl, 6.78; N, 10.71; O, 21.42; S, 6.13
TECHNICAL DATA
REFERENCES
1: Ikuta K, Yano S, Trung VT, Hanibuchi M, Goto H, Li Q, Wang W, Yamada T, Ogino H, Kakiuchi S, Uehara H, Sekido Y, Uenaka T, Nishioka Y, Sone S. E7080, a multi-tyrosine kinase inhibitor, suppresses the progression of malignant pleural mesothelioma with different proangiogenic cytokine production profiles. Clin Cancer Res. 2009 Dec 1;15(23):7229-37. Epub 2009 Nov 24. PubMed PMID: 19934291.
2: Okamoto N, Chantangsi C, Horák A, Leander BS, Keeling PJ. Molecular phylogeny and description of the novel katablepharid Roombia truncata gen. et sp. nov., and establishment of the Hacrobia taxon nov. PLoS One. 2009 Sep 17;4(9):e7080. PubMed PMID: 19759916; PubMed Central PMCID: PMC2741603.
3: Matsui J, Funahashi Y, Uenaka T, Watanabe T, Tsuruoka A, Asada M. Multi-kinase inhibitor E7080 suppresses lymph node and lung metastases of human mammary breast tumor MDA-MB-231 via inhibition of vascular endothelial growth factor-receptor (VEGF-R) 2 and VEGF-R3 kinase. Clin Cancer Res. 2008 Sep 1;14(17):5459-65. PubMed PMID: 18765537.
4: Koyama N, Magario N, Yamamoto Y, Matsui J, Tsuruoka A. [Anti-tumor effect of E7080, a novel angiogenesis inhibitor]. Nippon Yakurigaku Zasshi. 2008 Aug;132(2):100-4. Review. Japanese. PubMed PMID: 18689959.
5: Matsui J, Yamamoto Y, Funahashi Y, Tsuruoka A, Watanabe T, Wakabayashi T, Uenaka T, Asada M. E7080, a novel inhibitor that targets multiple kinases, has potent antitumor activities against stem cell factor producing human small cell lung cancer H146, based on angiogenesis inhibition. Int J Cancer. 2008 Feb 1;122(3):664-71. PubMed PMID: 17943726.
