Palbociclib
CAS#: 571190-30-2 (free base)
Description: Palbociclib, also known as PD-0332991, is an orally available cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. Palbociclib selectively inhibits cyclin-dependent kinase 4 (CDK4) and 6 (CDK6), thereby inhibiting retinoblastoma (Rb) protein phosphorylation early in the G1 phase leading to cell cycle arrest. This suppresses DNA replication and decreases tumor cell proliferation. CDK4 and 6 are serine/threonine kinases that are upregulated in many tumor cell types and play a key role in the regulation of cell cycle progression. Palbociclib, was approved on February 3, 2015 as a treatment (in combination with letrozole) for patients with estrogen receptor-positive advanced breast cancer.
Synonym: PD-0332991; PD 0332991; PD0332991; Palbociclib free base, brand name: Ibrance.
IUPAC/Chemical Name: 6-acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one
THEORETICAL ANALYSIS
Name: Palbociclib free base
CAS#: 571190-30-2 (free base)
Chemical Formula: C24H29N7O2
Exact Mass: 447.23827
Molecular Weight: 447.543
Elemental Analysis: C, 64.41; H, 6.53; N, 21.91; O, 7.15
TECHNICAL DATA
ADDITIONAL INFORMATION
CAS# related to Palbociclib
CAS#571190-30-2 (Palbociclib free base);
CAS# 827022-32-2 ( PalbociclibHCl salt);
CAS#827022-33-3 (Palbociclib Isethionate)
REFERENCES
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