Olmutinib
CAS#: 1353550-13-6 (free base)
Description: Olmutinib, also known as HM61713 and BI-1482694, is a potent small molecule inhibitor of Bruton’s tyrosine kinase (BTK). BTK is a member of the Tec family of non-receptor protein tyrosine kinases. BTK is mostly expressed in hematopoietic cells such as B cells, mast cells and macrophages. BTK plays key roles in multiple cell signaling pathways including B-Cell Receptor (BCR) and Fc receptor (FcR) signaling cascades and is an essential mediator not only in B-cell dependent but also in myeloid cell dependent inflammatory arthritis. HM71224 has been selected as a novel therapeutic agent for the treatment of autoimmune diseases such as RA.
Synonym: HM61713; HM 61713; HM-61713; BI 1482694; BI-1482694; BI1482694; Olmutinib.
IUPAC/Chemical Name: N-(3-((2-((4-(4-methylpiperazin-1-yl)phenyl)amino)thieno[3,2-d]pyrimidin-4-yl)oxy)phenyl)acrylamide
THEORETICAL ANALYSIS
Name: Olmutinib free base
CAS#: 1353550-13-6 (free base)
Chemical Formula: C26H26N6O2S
Exact Mass: 486.18379
Molecular Weight: 486.59
Elemental Analysis: C, 64.18; H, 5.39; N, 17.27; O, 6.58; S, 6.59
TECHNICAL DATA
ADDITIONAL INFORMATION
Related CAS#
1353550-13-6 (free base); 1842366-97-5 (HCl).
1802181-20-9 (deleted CAS#)
Note: Olmutinib was previously mistakely cited as “HM71224”. As of 9/12/2016, there are many vendor still cit
REFERENCES
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