Upadacitinib -Biokitchen

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Upadacitinib

Time：2016-10-31

CAS#: 1310726-60-3

Description: Upadacitinib, also known as ABT-494, is a potent and selective JAK inhibitors in development for rheumatoid arthritis. ABT-494 is approximately 74 fold selective for Jak1 over Jak2 in cellular assays dependent on specific, relevant cytokines. ABT-494 demonstrates efficacy in rat arthritis models. Preliminary evidence suggests that compared to tofacitinib, ABT-494 may spare Jak2 and Jak3 dependent signaling.

Synonym: ABT-494; ABT 494; ABT494. Upadacitinib.

IUPAC/Chemical Name: (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide

PRICE AND AVAILABILITY

Size Price

10mg Not available

100mg Not available

1g Ask price

Upadacitinib (ABT-494) is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to business@biokitchen.net to inquire quote.

THEORETICAL ANALYSIS

Name: Upadacitinib (ABT-494)
CAS#: 1310726-60-3
Chemical Formula: C17H19F3N6O
Exact Mass: 380.1572
Molecular Weight: 380.3752
Elemental Analysis: C, 53.68; H, 5.04; F, 14.98; N, 22.09; O, 4.21

TECHNICAL DATA

Appearance:

Solid powder

Purity:

>98% (or refer to the Certificate of Analysis)

Shipping Condition:

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:

Dry, dark and at 0 – 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:

Soluble in DMSO, not in water

Shelf Life:

>2 years if stored properly

Drug Formulation:

This drug may be formulated in DMSO

Stock Solution Storage:

0 – 4 C for short term (days to weeks), or -20 C for long term (months).

REFERENCES

1: Norman P. Selective JAK inhibitors in development for rheumatoid arthritis.
Expert Opin Investig Drugs. 2014 Aug;23(8):1067-77. doi:
10.1517/13543784.2014.918604. Epub 2014 May 12. Review. PubMed PMID: 24818516.

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