Filgotinib
CAS#: 1206161-97-8
Description: Filgotinib, also known as GLPG0634, is a potent and selective JAK1 inhibitor under investigation for the treatment of rheumatoid arthritis (RA) and Crohn’s disease. It is considered a promising agent as it inhibits JAK1 selectively. Filgotinib displayed a selectivity of 30-fold for JAK1- over JAK2-dependent signaling. GLPG0634 dose-dependently inhibited Th1 and Th2 differentiation and to a lesser extent the differentiation of Th17 cells in vitro.
Synonym: GLPG0634; GLPG 0634; GLPG-0634. Filgotinib; PubChemSID 163643231
IUPAC/Chemical Name: N-(5-(4-((1,1-dioxidothiomorpholino)methyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide.
THEORETICAL ANALYSIS
Name: Filgotinib (GLPG0634)
CAS#: 1206161-97-8
Chemical Formula: C21H23N5O3S
Exact Mass: 425.15216
Molecular Weight: 425.5
Elemental Analysis: C, 59.28; H, 5.45; N, 16.46; O, 11.28; S, 7.54
TECHNICAL DATA
REFERENCES
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