Description: PF-06747775 is an orally available inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity. EGFR T790M inhibitor PF-06747775 specifically binds to and inhibits EGFR T790M, a secondarily acquired resistance mutation, which prevents EGFR-mediated signaling and leads to cell death in EGFR T790M-expressing tumor cells. Compared to some other EGFR inhibitors, PF-06747775 may have therapeutic benefits in tumors with T790M-mediated drug resistance.
Synonym: PF06747775; PF06747775; PF 06747775; PF6747775; PF 6747775; PF6747775.
IUPAC/Chemical Name: N-((3R,4R)-4-fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-methyl-9H-purin-2-yl)pyrrolidin-3-yl)acrylamide
PRICE AND AVAILABILITY
Chemical Formula: C18H22FN9O2
Exact Mass: 415.188
Molecular Weight: 415.4334
Elemental Analysis: C, 52.04; H, 5.34; F, 4.57; N, 30.34; O, 7.70