Description: Telotristat etiprate, its free base also known as LX1606 or LX1032, is an oral serotonin synthesis inhibitor or peripheral tryptophan hydroxylase (TPH) inhibitor . Telotristat etiprate has activity in controlling diarrhea associated with carcinoid syndrome. LX1606 acts by inhibiting the enzyme tryptophan hydoxylase (TPH) and reduces serotonin production both inside and outside the GI tract without affecting brain serotonin levels. TPH is the rate-limiting enzyme involved in serotonin biosynthesis and is present in metastatic carcinoid tumor cells.

Synonym: LX1032 etiprate; LX1032 etiprate; LX 1032 etiprate; LX1606; LX1606 etiprate; LX 1606; LX 1606 Hippurate; Telotristat etiprate;

IUPAC/Chemical Name: (S)-ethyl 2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoate 2-benzamidoacetate .

THEORETICAL ANALYSIS

Name: Telotristat etiprate
CAS#: 1137608-69-5 (etiprate)
Chemical Formula: C36H35ClF3N7O6
Exact Mass:
Molecular Weight: 754.16
Elemental Analysis: C, 57.33; H, 4.68; Cl, 4.70; F, 7.56; N, 13.00; O, 12.73

TECHNICAL DATA

ADDITIONAL INFORMATION

Related CAS#
CAS#1033805-22-9 (Telotristat ethyl)
CAS#1033805-28-5 (Telotristat)
CAS#1137608-69-5 (Telotristat etiprate)

REFERENCES

1: Kulke MH, O’Dorisio T, Phan A, Bergsland EK, Law L, Banks P, Freiman J, Frazier K, Jackson J, Yao JC, Kvols L, Lapuerta P, Zambrowicz B, Fleming D, Sands A. Telotristat etiprate in carcinoid syndrome not adequately controlled by octreotide. Endocr Relat Cancer. 2014 Jul 10. pii: ERC-14-0173. [Epub ahead of print] PubMed PMID: 25012985.