Selinexor
CAS#: 1393477-72-9
Description: Selinexor, also known as KPT-330, is an orally bioavailable, potent and selective XPO1/CRM1 Inhibitor. Selinexor is effective in acquired resistance to ibrutinib and synergizes with ibrutinib in chronic lymphocytic leukemia. Selinexor potentiates the antitumor activity of gemcitabine in human pancreatic cancer through inhibition of tumor growth, depletion of the antiapoptotic proteins, and induction of apoptosis. Selinexor has strong activity against primary AML cells while sparing normal stem and progenitor cells.
Synonym: KPT-330; KPT330; KPT 330; Selinexor.
IUPAC/Chemical Name: (Z)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N’-(pyrazin-2-yl)acrylohydrazide
PRICE AND AVAILABILITY
THEORETICAL ANALYSIS
Name: Selinexor (KPT-330)
CAS#: 1393477-72-9
Chemical Formula: C17H11F6N7O
Exact Mass: 443.09293
Molecular Weight: 443.31342
Elemental Analysis: C, 46.06; H, 2.50; F, 25.71; N, 22.12; O, 3.61
TECHNICAL DATA
REFERENCES
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